From dynamic chromatin architecture to DNA damage repair and back

Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense sc...

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Detalles Bibliográficos
Autores principales: Fabre, Emmanuelle, Zimmer, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Extra View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973241/
https://www.ncbi.nlm.nih.gov/pubmed/29271297
http://dx.doi.org/10.1080/19491034.2017.1419847
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author Fabre, Emmanuelle
Zimmer, Christophe
author_facet Fabre, Emmanuelle
Zimmer, Christophe
author_sort Fabre, Emmanuelle
collection PubMed
description Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus.
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spelling pubmed-59732412018-05-31 From dynamic chromatin architecture to DNA damage repair and back Fabre, Emmanuelle Zimmer, Christophe Nucleus Extra View Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus. Taylor & Francis 2018-01-30 /pmc/articles/PMC5973241/ /pubmed/29271297 http://dx.doi.org/10.1080/19491034.2017.1419847 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Extra View
Fabre, Emmanuelle
Zimmer, Christophe
From dynamic chromatin architecture to DNA damage repair and back
title From dynamic chromatin architecture to DNA damage repair and back
title_full From dynamic chromatin architecture to DNA damage repair and back
title_fullStr From dynamic chromatin architecture to DNA damage repair and back
title_full_unstemmed From dynamic chromatin architecture to DNA damage repair and back
title_short From dynamic chromatin architecture to DNA damage repair and back
title_sort from dynamic chromatin architecture to dna damage repair and back
topic Extra View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973241/
https://www.ncbi.nlm.nih.gov/pubmed/29271297
http://dx.doi.org/10.1080/19491034.2017.1419847
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