Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives

Mutations in LMNA, encoding A-type lamins, are responsible for laminopathies including muscular dystrophies, lipodystrophies, and premature ageing syndromes. LMNA mutations have been shown to alter nuclear structure and stiffness, binding to partners at the nuclear envelope or within the nucleoplasm...

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Detalles Bibliográficos
Autores principales: Vigouroux, Corinne, Guénantin, Anne-Claire, Vatier, Camille, Capel, Emilie, Le Dour, Caroline, Afonso, Pauline, Bidault, Guillaume, Béréziat, Véronique, Lascols, Olivier, Capeau, Jacqueline, Briand, Nolwenn, Jéru, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Laminopathies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973242/
https://www.ncbi.nlm.nih.gov/pubmed/29578370
http://dx.doi.org/10.1080/19491034.2018.1456217

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