Discontinuous transcription

Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to ma...

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Detalles Bibliográficos
Autores principales: Smirnov, Evgeny, Hornáček, Matúš, Vacík, Tomáš, Cmarko, Dušan, Raška, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973254/
https://www.ncbi.nlm.nih.gov/pubmed/29285985
http://dx.doi.org/10.1080/19491034.2017.1419112
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author Smirnov, Evgeny
Hornáček, Matúš
Vacík, Tomáš
Cmarko, Dušan
Raška, Ivan
author_facet Smirnov, Evgeny
Hornáček, Matúš
Vacík, Tomáš
Cmarko, Dušan
Raška, Ivan
author_sort Smirnov, Evgeny
collection PubMed
description Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to mammals, it now seems to be a common mode of gene expression. In this review we discuss the occurrence of the transcriptional fluctuations, the techniques used for their detection, their putative causes, kinetic characteristics, and probable physiological significance.
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spelling pubmed-59732542018-05-31 Discontinuous transcription Smirnov, Evgeny Hornáček, Matúš Vacík, Tomáš Cmarko, Dušan Raška, Ivan Nucleus Review Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to mammals, it now seems to be a common mode of gene expression. In this review we discuss the occurrence of the transcriptional fluctuations, the techniques used for their detection, their putative causes, kinetic characteristics, and probable physiological significance. Taylor & Francis 2018-01-30 /pmc/articles/PMC5973254/ /pubmed/29285985 http://dx.doi.org/10.1080/19491034.2017.1419112 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Smirnov, Evgeny
Hornáček, Matúš
Vacík, Tomáš
Cmarko, Dušan
Raška, Ivan
Discontinuous transcription
title Discontinuous transcription
title_full Discontinuous transcription
title_fullStr Discontinuous transcription
title_full_unstemmed Discontinuous transcription
title_short Discontinuous transcription
title_sort discontinuous transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973254/
https://www.ncbi.nlm.nih.gov/pubmed/29285985
http://dx.doi.org/10.1080/19491034.2017.1419112
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