Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosome-Y (mLOY), and its clinical relevance, are unknown. Using genotype array intensity data and sequence reads in 85,542 men, we i...

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Detalles Bibliográficos
Autores principales: Wright, Daniel J., Day, Felix R., Kerrison, Nicola D., Zink, Florian, Cardona, Alexia, Sulem, Patrick, Thompson, Deborah J., Sigurjonsdottir, Svanhvit, Gudbjartsson, Daniel F, Helgason, Agnar, Chapman, J. Ross, Jackson, Steve P., Langenberg, Claudia, Wareham, Nicholas J., Scott, Robert A., Thorsteindottir, Unnur, Ong, Ken K., Stefansson, Kari, Perry, John R.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973269/
https://www.ncbi.nlm.nih.gov/pubmed/28346444
http://dx.doi.org/10.1038/ng.3821

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