异硫氰酸酯抗肿瘤作用机制研究新进展

Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and produ...

Descripción completa

Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2017
Materias:
综述
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973296/
https://www.ncbi.nlm.nih.gov/pubmed/28302225
http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11
_version_ 1783326587881521152
collection PubMed
description Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs.
format Online
Article
Text
id pubmed-5973296
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher 中国肺癌杂志编辑部
record_format MEDLINE/PubMed
spelling pubmed-59732962018-07-06 异硫氰酸酯抗肿瘤作用机制研究新进展 Zhongguo Fei Ai Za Zhi 综述 Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs. 中国肺癌杂志编辑部 2017-03-20 /pmc/articles/PMC5973296/ /pubmed/28302225 http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11 Text en 版权所有©《中国肺癌杂志》编辑部2017 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 综述
异硫氰酸酯抗肿瘤作用机制研究新进展
title 异硫氰酸酯抗肿瘤作用机制研究新进展
title_full 异硫氰酸酯抗肿瘤作用机制研究新进展
title_fullStr 异硫氰酸酯抗肿瘤作用机制研究新进展
title_full_unstemmed 异硫氰酸酯抗肿瘤作用机制研究新进展
title_short 异硫氰酸酯抗肿瘤作用机制研究新进展
title_sort 异硫氰酸酯抗肿瘤作用机制研究新进展
topic 综述
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973296/
https://www.ncbi.nlm.nih.gov/pubmed/28302225
http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11
work_keys_str_mv AT yìliúqíngsuānzhǐkàngzhǒngliúzuòyòngjīzhìyánjiūxīnjìnzhǎn
AT yìliúqíngsuānzhǐkàngzhǒngliúzuòyòngjīzhìyánjiūxīnjìnzhǎn

Ejemplares similares