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Valium without dependence? Individual GABA(A) receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA)(A) receptors revealed distinct contributions from ea...

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Detalles Bibliográficos
Autores principales: Cheng, Tianze, Wallace, Dominique Marie, Ponteri, Benjamin, Tuli, Mahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973310/
https://www.ncbi.nlm.nih.gov/pubmed/29872302
http://dx.doi.org/10.2147/NDT.S164307
Descripción
Sumario:Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA)(A) receptors revealed distinct contributions from each subtype and produced effects. Recent findings have highlighted the importance of α(1) containing GABA(A) receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance. A valium-like drug without its side effects, as repeatedly demonstrated in animals, is achievable.