基于Oncomine数据库荟萃分析KIF23在非小细胞肺癌中的表达和意义

BACKGROUND AND OBJECTIVE: Non-small cell lung cancer (NSCLC) is one of the most common cause of cancer-related death worldwide. As the overall prognosis for affected patients is still poor, there is a need for biomarkers for prediction of survival and guiding individual therapy. This study is to explore the expression and significance of kinesin family member 23 (KIF23) in NSCLC. METHODS: KIF23 data were retrieved from Oncomine NSCLC database. The prognostic value of KIF23 was retrieved from an online survival analysis tool "Kaplan-Meier Plotter" (KM plotter) database. RESULTS: In Oncomine database, there were 447 studies of different types concerning expression of KIF23, of which 67 studies were of statistically significance (64 up-regulated and 3 down-regulated). A total of 16 studies were involved KIF23 in NSCLC tissues and normal tissues, including a total of 1, 189 samples. Overall, KIF23 expression in NSCLC is higher than that in normal tissues (P < 0.05). Moreover, Kaplan-Meier plots of overall survival indicated that KIF23 high expression is closely associated with poor survival in NSCLC (P < 0.05). Subgroup analysis revealed that KIF23 expression showed negative relation to the prognosis of pulmonary adenocarcinoma patients. Whereas, in those with squamous carcinoma KIF23 expression showed no effects on the prognosis of the patients. CONCLUSION: KIF23 was found highly expressed in NSCLC, which might be a marker for NSCLC prognosis.