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Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer

Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct cancer initiating mechanisms. Although 85% of sporadic CRC reveal CIN, 15% reveal mismatch repair (MMR) malfunct...

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Detalles Bibliográficos
Autores principales:	Pussila, Marjaana, Törönen, Petri, Einarsdottir, Elisabet, Katayama, Shintaro, Krjutškov, Kaarel, Holm, Liisa, Kere, Juha, Peltomäki, Päivi, Mäkinen, Markus J, Linden, Jere, Nyström, Minna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Cancer Biomarkers and Molecular Epidemiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973430/ https://www.ncbi.nlm.nih.gov/pubmed/29701748 http://dx.doi.org/10.1093/carcin/bgy056

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