Dexmedetomidine attenuates persistent postsurgical pain by upregulating K(+)–Cl(−) cotransporter-2 in the spinal dorsal horn in rats

BACKGROUND: Dexmedetomidine (DEX) could have an analgesic effect on pain transmission through the modulation of brain-derived neurotrophic factor (BDNF). In addition, KCC2-induced shift in neuronal Cl− homeostasis is crucial for postsynaptic inhibition mediated by GABAA receptors. Accumulating evide...

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Detalles Bibliográficos
Autores principales: Dai, Shuhong, Qi, Yu, Fu, Jie, Li, Na, Zhang, Xu, Zhang, Juan, Zhang, Wei, Xu, Haijun, Zhou, Hai, Ma, Zhengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973459/
https://www.ncbi.nlm.nih.gov/pubmed/29872336
http://dx.doi.org/10.2147/JPR.S158737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973459/
https://www.ncbi.nlm.nih.gov/pubmed/29872336
http://dx.doi.org/10.2147/JPR.S158737

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