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Dexmedetomidine attenuates persistent postsurgical pain by upregulating K(+)–Cl(−) cotransporter-2 in the spinal dorsal horn in rats

BACKGROUND: Dexmedetomidine (DEX) could have an analgesic effect on pain transmission through the modulation of brain-derived neurotrophic factor (BDNF). In addition, KCC2-induced shift in neuronal Cl− homeostasis is crucial for postsynaptic inhibition mediated by GABAA receptors. Accumulating evide...

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Detalles Bibliográficos
Autores principales:	Dai, Shuhong, Qi, Yu, Fu, Jie, Li, Na, Zhang, Xu, Zhang, Juan, Zhang, Wei, Xu, Haijun, Zhou, Hai, Ma, Zhengliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973459/ https://www.ncbi.nlm.nih.gov/pubmed/29872336 http://dx.doi.org/10.2147/JPR.S158737

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