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Nanoparticles as multimodal photon transducers of ionizing radiation

In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies, and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuc...

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Detalles Bibliográficos
Autores principales: Pratt, Edwin C., Shaffer, Travis M., Zhang, Qize, Drain, Charles Michael, Grimm, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973484/
https://www.ncbi.nlm.nih.gov/pubmed/29581551
http://dx.doi.org/10.1038/s41565-018-0086-2
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author Pratt, Edwin C.
Shaffer, Travis M.
Zhang, Qize
Drain, Charles Michael
Grimm, Jan
author_facet Pratt, Edwin C.
Shaffer, Travis M.
Zhang, Qize
Drain, Charles Michael
Grimm, Jan
author_sort Pratt, Edwin C.
collection PubMed
description In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies, and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be explained by only Cerenkov luminescence interactions with nanoparticles. Herein, we report methods to examine the mechanisms of nanoparticle excitation by radionuclides, including interactions with Cerenkov luminescence, β particles, and γ radiation. We demonstrate that β scintillation contributes appreciably to excitation and reactivity in certain nanoparticle systems and that excitation of nanoparticles composed of large atomic number atoms by radionuclides generates X-rays, enabling multiplexed imaging through single photon emission computed tomography. These findings demonstrate practical optical imaging and therapy using radionuclides with emission energies below the Cerenkov threshold, thereby expanding the list of applicable radionuclides.
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spelling pubmed-59734842018-09-26 Nanoparticles as multimodal photon transducers of ionizing radiation Pratt, Edwin C. Shaffer, Travis M. Zhang, Qize Drain, Charles Michael Grimm, Jan Nat Nanotechnol Article In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies, and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be explained by only Cerenkov luminescence interactions with nanoparticles. Herein, we report methods to examine the mechanisms of nanoparticle excitation by radionuclides, including interactions with Cerenkov luminescence, β particles, and γ radiation. We demonstrate that β scintillation contributes appreciably to excitation and reactivity in certain nanoparticle systems and that excitation of nanoparticles composed of large atomic number atoms by radionuclides generates X-rays, enabling multiplexed imaging through single photon emission computed tomography. These findings demonstrate practical optical imaging and therapy using radionuclides with emission energies below the Cerenkov threshold, thereby expanding the list of applicable radionuclides. 2018-03-26 2018-05 /pmc/articles/PMC5973484/ /pubmed/29581551 http://dx.doi.org/10.1038/s41565-018-0086-2 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pratt, Edwin C.
Shaffer, Travis M.
Zhang, Qize
Drain, Charles Michael
Grimm, Jan
Nanoparticles as multimodal photon transducers of ionizing radiation
title Nanoparticles as multimodal photon transducers of ionizing radiation
title_full Nanoparticles as multimodal photon transducers of ionizing radiation
title_fullStr Nanoparticles as multimodal photon transducers of ionizing radiation
title_full_unstemmed Nanoparticles as multimodal photon transducers of ionizing radiation
title_short Nanoparticles as multimodal photon transducers of ionizing radiation
title_sort nanoparticles as multimodal photon transducers of ionizing radiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973484/
https://www.ncbi.nlm.nih.gov/pubmed/29581551
http://dx.doi.org/10.1038/s41565-018-0086-2
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