A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3

Identifying monoclonal antibodies that block human voltage-gated ion channels (VGICs) is a challenging endeavor exacerbated by difficulties in producing recombinant ion channel proteins in amounts that support drug discovery programs. We have developed a general strategy to address this challenge by...

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Detalles Bibliográficos
Autores principales: Bednenko, Janna, Harriman, Rian, Mariën, Lore, Nguyen, Hai M., Agrawal, Alka, Papoyan, Ashot, Bisharyan, Yelena, Cardarelli, Joanna, Cassidy-Hanley, Donna, Clark, Ted, Pedersen, Darlene, Abdiche, Yasmina, Harriman, William, van der Woning, Bas, de Haard, Hans, Collarini, Ellen, Wulff, Heike, Colussi, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973702/
https://www.ncbi.nlm.nih.gov/pubmed/29494279
http://dx.doi.org/10.1080/19420862.2018.1445451

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