When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions

Monoclonal antibodies are commonly assumed to be monospecific, but anecdotal studies have reported genetic diversity in antibody heavy chain and light chain genes found within individual hybridomas. As the prevalence of such diversity has never been explored, we analyzed 185 random hybridomas, in a...

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Detalles Bibliográficos
Autores principales: Bradbury, Andrew R. M., Trinklein, Nathan D., Thie, Holger, Wilkinson, Ian C., Tandon, Atul K., Anderson, Stephen, Bladen, Catherine L., Jones, Brittany, Aldred, Shelley Force, Bestagno, Marco, Burrone, Oscar, Maynard, Jennifer, Ferrara, Fortunato, Trimmer, James S., Görnemann, Janina, Glanville, Jacob, Wolf, Philipp, Frenzel, Andre, Wong, Julin, Koh, Xin Yu, Eng, Hui-Yan, Lane, David, Lefranc, Marie-Paule, Clark, Mike, Dübel, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973764/
https://www.ncbi.nlm.nih.gov/pubmed/29485921
http://dx.doi.org/10.1080/19420862.2018.1445456

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