(89)Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

Cergutuzumab amunaleukin (CEA-IL2v) is an immunocytokine directed against carcinoembryonic antigen (CEA) containing an IL2v-moiety with abolished IL-2 receptor (IL-2R) α binding. We describe the biodistribution and tumor accumulation of (89)Zr-labeled CEA-IL2v. Twenty-four patients with advanced sol...

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Detalles Bibliográficos
Autores principales: van Brummelen, Emilie M.J., Huisman, Marc C., de Wit-van der Veen, Linda J., Nayak, Tapan K., Stokkel, Marcel P.M., Mulder, Emma R., Hoekstra, Otto S., Vugts, Danielle J., Van Dongen, Guus A.M.S., Verheul, Henk M., Evers, Stefan, Tessier, Jean J. L., Saro, Jose, Schellens, Jan H.M., Menke-van der Houven van Oordt, C. Willemien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973872/
https://www.ncbi.nlm.nih.gov/pubmed/29872502
http://dx.doi.org/10.18632/oncotarget.25343

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