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Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients
BACKGROUND: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Laboratory Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973919/ https://www.ncbi.nlm.nih.gov/pubmed/29797815 http://dx.doi.org/10.3343/alm.2018.38.5.446 |
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author | Karakecili, Faruk Cikman, Aytekin Aydin, Merve Gulhan, Baris |
author_facet | Karakecili, Faruk Cikman, Aytekin Aydin, Merve Gulhan, Baris |
author_sort | Karakecili, Faruk |
collection | PubMed |
description | BACKGROUND: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). METHODS: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADMA levels were quantified using an ELISA kit (Cusabio, Wuhan, China). The data were analyzed using an ANOVA or the Kruskal-Wallis test as appropriate, with P<0.05 considered significant. RESULTS: Serum ADMA levels were significantly higher in patients with CHB (228.35±91.10 ng/mL) than in HBV carriers (207.80±75.80 ng/mL) and controls (207.61±89.10 ng/mL) (P=0.049). The clinical scores of the patients were positively correlated with ADMA levels. CONCLUSIONS: The elevated serum ADMA levels in patients with CHB confirm that HBV plays a role in vasculitis. Further investigation of the mechanisms contributing to the high levels of ADMA in CHB may contribute toward development of new treatment modalities. |
format | Online Article Text |
id | pubmed-5973919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Society for Laboratory Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-59739192018-09-01 Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients Karakecili, Faruk Cikman, Aytekin Aydin, Merve Gulhan, Baris Ann Lab Med Original Article BACKGROUND: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). METHODS: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADMA levels were quantified using an ELISA kit (Cusabio, Wuhan, China). The data were analyzed using an ANOVA or the Kruskal-Wallis test as appropriate, with P<0.05 considered significant. RESULTS: Serum ADMA levels were significantly higher in patients with CHB (228.35±91.10 ng/mL) than in HBV carriers (207.80±75.80 ng/mL) and controls (207.61±89.10 ng/mL) (P=0.049). The clinical scores of the patients were positively correlated with ADMA levels. CONCLUSIONS: The elevated serum ADMA levels in patients with CHB confirm that HBV plays a role in vasculitis. Further investigation of the mechanisms contributing to the high levels of ADMA in CHB may contribute toward development of new treatment modalities. The Korean Society for Laboratory Medicine 2018-09 2018-05-23 /pmc/articles/PMC5973919/ /pubmed/29797815 http://dx.doi.org/10.3343/alm.2018.38.5.446 Text en © The Korean Society for Laboratory Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Karakecili, Faruk Cikman, Aytekin Aydin, Merve Gulhan, Baris Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title | Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title_full | Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title_fullStr | Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title_full_unstemmed | Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title_short | Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients |
title_sort | asymmetrical dimethylarginine levels in hepatitis b virus-positive patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973919/ https://www.ncbi.nlm.nih.gov/pubmed/29797815 http://dx.doi.org/10.3343/alm.2018.38.5.446 |
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