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The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia

The 2016 WHO diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (≥1×10(9)/L and ≥10% of white blood cell counts) in peripheral blood. Moreover, myeloproliferative neoplasm (MPN) features in bone marrow and/or MPN-associated mutations tend to...

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Autores principales: Moon, Yeonsook, Kim, Mi Hyang, Kim, Hye Ryoun, Ahn, Jeong-Yeal, Huh, Jungwon, Huh, Ji Young, Han, Jae Ho, Park, Joon Seong, Cho, Sung Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973924/
https://www.ncbi.nlm.nih.gov/pubmed/29797820
http://dx.doi.org/10.3343/alm.2018.38.5.481
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author Moon, Yeonsook
Kim, Mi Hyang
Kim, Hye Ryoun
Ahn, Jeong-Yeal
Huh, Jungwon
Huh, Ji Young
Han, Jae Ho
Park, Joon Seong
Cho, Sung Ran
author_facet Moon, Yeonsook
Kim, Mi Hyang
Kim, Hye Ryoun
Ahn, Jeong-Yeal
Huh, Jungwon
Huh, Ji Young
Han, Jae Ho
Park, Joon Seong
Cho, Sung Ran
author_sort Moon, Yeonsook
collection PubMed
description The 2016 WHO diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (≥1×10(9)/L and ≥10% of white blood cell counts) in peripheral blood. Moreover, myeloproliferative neoplasm (MPN) features in bone marrow and/or MPN-associated mutations tend to support MPN with monocytosis rather than CMML. We assessed the impact of the 2016 WHO criteria on CMML diagnosis, compared with the 2008 WHO criteria, through a retrospective review of the medical records of 38 CMML patients diagnosed according to the 2008 WHO classification. Application of the 2016 WHO criteria resulted in the exclusion of three (8%) patients who did not fulfill the relative monocytosis criterion and eight (21%) patients with an MPN-associated mutation. These 11 patients formed the 2016 WHO others group; the remaining 27 formed the 2016 WHO CMML group. The significant difference in the platelet count and monocyte percentage between the two groups indicated that the 2016 WHO criteria lead to a more homogenous and improved definition of CMML compared with the 2008 WHO criteria, which may have led to over-diagnosis of CMML. More widespread use of molecular tests and more sophisticated clinical and morphological evaluations are necessary to diagnose CMML accurately.
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spelling pubmed-59739242018-09-01 The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia Moon, Yeonsook Kim, Mi Hyang Kim, Hye Ryoun Ahn, Jeong-Yeal Huh, Jungwon Huh, Ji Young Han, Jae Ho Park, Joon Seong Cho, Sung Ran Ann Lab Med Brief Communication The 2016 WHO diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (≥1×10(9)/L and ≥10% of white blood cell counts) in peripheral blood. Moreover, myeloproliferative neoplasm (MPN) features in bone marrow and/or MPN-associated mutations tend to support MPN with monocytosis rather than CMML. We assessed the impact of the 2016 WHO criteria on CMML diagnosis, compared with the 2008 WHO criteria, through a retrospective review of the medical records of 38 CMML patients diagnosed according to the 2008 WHO classification. Application of the 2016 WHO criteria resulted in the exclusion of three (8%) patients who did not fulfill the relative monocytosis criterion and eight (21%) patients with an MPN-associated mutation. These 11 patients formed the 2016 WHO others group; the remaining 27 formed the 2016 WHO CMML group. The significant difference in the platelet count and monocyte percentage between the two groups indicated that the 2016 WHO criteria lead to a more homogenous and improved definition of CMML compared with the 2008 WHO criteria, which may have led to over-diagnosis of CMML. More widespread use of molecular tests and more sophisticated clinical and morphological evaluations are necessary to diagnose CMML accurately. The Korean Society for Laboratory Medicine 2018-09 2018-05-23 /pmc/articles/PMC5973924/ /pubmed/29797820 http://dx.doi.org/10.3343/alm.2018.38.5.481 Text en © The Korean Society for Laboratory Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Moon, Yeonsook
Kim, Mi Hyang
Kim, Hye Ryoun
Ahn, Jeong-Yeal
Huh, Jungwon
Huh, Ji Young
Han, Jae Ho
Park, Joon Seong
Cho, Sung Ran
The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title_full The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title_fullStr The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title_full_unstemmed The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title_short The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
title_sort 2016 who versus 2008 who criteria for the diagnosis of chronic myelomonocytic leukemia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973924/
https://www.ncbi.nlm.nih.gov/pubmed/29797820
http://dx.doi.org/10.3343/alm.2018.38.5.481
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