Cargando…

Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling

Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in the early phases of acute kidney injury is poorly understood. Here, we investigated the role of complement in induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castellano, Giuseppe, Franzin, Rossana, Stasi, Alessandra, Divella, Chiara, Sallustio, Fabio, Pontrelli, Paola, Lucarelli, Giuseppe, Battaglia, Michele, Staffieri, Francesco, Crovace, Antonio, Stallone, Giovanni, Seelen, Marc, Daha, Mohamed R., Grandaliano, Giuseppe, Gesualdo, Loreto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974049/ https://www.ncbi.nlm.nih.gov/pubmed/29875766 http://dx.doi.org/10.3389/fimmu.2018.01002

Ejemplares similares

LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling
por: Castellano, Giuseppe, et al.
Publicado: (2019)

Pentraxin-3-mediated complement activation in a swine model of renal ischemia/reperfusion injury
por: Divella, Chiara, et al.
Publicado: (2021)

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury
por: Castellano, Giuseppe, et al.
Publicado: (2019)

Extracellular vesicles derived from patients with antibody‐mediated rejection induce tubular senescence and endothelial to mesenchymal transition in renal cells
por: Franzin, Rossana, et al.
Publicado: (2022)

PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury
por: Stasi, Alessandra, et al.
Publicado: (2021)

Endothelial dysfunction and renal fibrosis in endotoxemia-induced oliguric kidney injury: possible role of LPS-binding protein
por: Castellano, Giuseppe, et al.
Publicado: (2014)

Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells
por: Castellano, Giuseppe, et al.
Publicado: (2015)

The Role of Natural Killer Cells in the Immune Response in Kidney Transplantation
por: Pontrelli, Paola, et al.
Publicado: (2020)

Coagulation and Fibrinolysis in Kidney Graft Rejection
por: Stallone, Giovanni, et al.
Publicado: (2020)

Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma
por: Gigante, Margherita, et al.
Publicado: (2015)

Modulation of complement activation by pentraxin-3 in prostate cancer
por: Stallone, Giovanni, et al.
Publicado: (2020)

Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage
por: Franzin, Rossana, et al.
Publicado: (2020)

Corrigendum: Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage
por: Franzin, Rossana, et al.
Publicado: (2021)

Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials
por: Franzin, Rossana, et al.
Publicado: (2021)

Role of Toll-Like Receptors in Actuating Stem/Progenitor Cell Repair Mechanisms: Different Functions in Different Cells
por: Sallustio, Fabio, et al.
Publicado: (2019)

On-line hemodiafiltration modulates atherosclerosis signaling in peripheral lymphomonocytes of hemodialysis patients
por: Simone, Simona, et al.
Publicado: (2021)

Emerging Biomarkers in Renal Damage
por: Ditonno, Pasquale, et al.
Publicado: (2014)

Acute Kidney Injury in Kidney Transplant Patients in Intensive Care Unit: From Pathogenesis to Clinical Management
por: Fiorentino, Marco, et al.
Publicado: (2023)

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction
por: Infante, Barbara, et al.
Publicado: (2021)

Pre-Transplant Expression of CCR-2 in Kidney Transplant Recipients Is Associated With the Development of Delayed Graft Function
por: Pontrelli, Paola, et al.
Publicado: (2022)

New Frontiers in Sepsis-Induced Acute Kidney Injury and Blood Purification Therapies: The Role of Polymethylmethacrylate Membrane Hemofilter
por: Stasi, Alessandra, et al.
Publicado: (2023)

Altered Phosphorylation of Cytoskeleton Proteins in Peripheral Blood Mononuclear Cells Characterizes Chronic Antibody-Mediated Rejection in Kidney Transplantation
por: Rocchetti, Maria Teresa, et al.
Publicado: (2020)

Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project
por: Stasi, Alessandra, et al.
Publicado: (2023)

Role of Complement in Regulating Inflammation Processes in Renal and Prostate Cancers
por: Netti, Giuseppe Stefano, et al.
Publicado: (2021)

Enhancing Immune Protection in Hemodialysis Patients: Role of the Polymethyl Methacrylate Membrane
por: Franzin, Rossana, et al.
Publicado: (2023)

Adult Renal Stem/Progenitor Cells Can Modulate T Regulatory Cells and Double Negative T Cells
por: Curci, Claudia, et al.
Publicado: (2020)

Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles
por: Franzin, Rossana, et al.
Publicado: (2023)

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications
por: Stasi, Alessandra, et al.
Publicado: (2021)

Recurrence of immunoglobulin A nephropathy after kidney transplantation: a narrative review of the incidence, risk factors, pathophysiology and management of immunosuppressive therapy
por: Infante, Barbara, et al.
Publicado: (2020)

Why stem/progenitor cells lose their regenerative potential
por: Picerno, Angela, et al.
Publicado: (2021)

SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure
por: Stasi, Alessandra, et al.
Publicado: (2020)

The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
por: Franzin, Rossana, et al.
Publicado: (2020)

Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice
por: Pontrelli, Paola, et al.
Publicado: (2021)

PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma
por: Netti, Giuseppe Stefano, et al.
Publicado: (2020)

Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials
por: Franzin, Rossana, et al.
Publicado: (2021)

Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay between Innate and Adaptive Immune Dysfunction
por: Losappio, Vincenzo, et al.
Publicado: (2020)

Recent advances in molecular mechanisms of acute kidney injury in patients with diabetes mellitus
por: Infante, Barbara, et al.
Publicado: (2023)

Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma
por: Papale, Massimo, et al.
Publicado: (2017)

Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway
por: Troise, Dario, et al.
Publicado: (2023)

The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
por: Spadaccino, Federica, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l05g6b0sujr0mqr7qekp9mkbag