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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independen...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974083/ https://www.ncbi.nlm.nih.gov/pubmed/29844566 http://dx.doi.org/10.1038/s41467-018-04362-x |
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| author | Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Böhmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kähönen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimäki, Terho Li, Shu-Chen Lill, Christina M. Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikäinen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumaré, Aïcha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stéphanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hägg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Räikkönen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Dan Rujescu Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H. Bressler, Jan Lencz, Todd Deary, Ian J. |
| author_facet | Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Böhmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kähönen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimäki, Terho Li, Shu-Chen Lill, Christina M. Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikäinen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumaré, Aïcha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stéphanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hägg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Räikkönen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Dan Rujescu Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H. Bressler, Jan Lencz, Todd Deary, Ian J. |
| author_sort | Davies, Gail |
| collection | PubMed |
| description | General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10(−8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function. |
| format | Online Article Text |
| id | pubmed-5974083 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59740832018-05-31 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Böhmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kähönen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimäki, Terho Li, Shu-Chen Lill, Christina M. Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikäinen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumaré, Aïcha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stéphanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hägg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Räikkönen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Dan Rujescu Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H. Bressler, Jan Lencz, Todd Deary, Ian J. Nat Commun Article General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10(−8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function. Nature Publishing Group UK 2018-05-29 /pmc/articles/PMC5974083/ /pubmed/29844566 http://dx.doi.org/10.1038/s41467-018-04362-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Böhmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kähönen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimäki, Terho Li, Shu-Chen Lill, Christina M. Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikäinen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumaré, Aïcha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stéphanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hägg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Räikkönen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Dan Rujescu Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H. Bressler, Jan Lencz, Todd Deary, Ian J. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title_full | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title_fullStr | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title_full_unstemmed | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title_short | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| title_sort | study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974083/ https://www.ncbi.nlm.nih.gov/pubmed/29844566 http://dx.doi.org/10.1038/s41467-018-04362-x |
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studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT smithjennifera studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT smithalbertv studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT terzikhannatalie studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT thalamuthuanbupalam studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT trompetstella studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT vanderleesvenj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wareerinb studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT windhambgwen studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wrightmargaretj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT yangjingyun studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT yujin studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT amesdavid studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT aminnajaf studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT amouyelphilippe studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT andreassenolea studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT armstrongnicolaj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT assarehameliaa studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT attiajohnr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT attixdeborah studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT avramopoulosdimitrios studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT bennettdavida studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT bohmerannec studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT boylepatriciaa studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT brodatyhenry studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT campbellharry studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT cannontyroned studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT cirullielizabetht studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT congdoneliza studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT conleyemilydrabant studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT corleyjanie studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT coxsimonr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT daleandersm studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT dehghanabbas studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT dickdanielle studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT dickinsondwight studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT erikssonjohang studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT evangelouevangelos studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT fauljessicad studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT fordian studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT freimernelsona studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gaohe studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gieglingina studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gillespienathana studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gordonscottd studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gottesmanrebeccaf studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT griswoldmichaele studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gudnasonvilmundur studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT harristamarab studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT hartmannannettem studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT hatzimanolisalex studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT heissgerardo studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT hollidayelizabethg studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT joshipeterk studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kahonenmika studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kardiasharonlr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT karlssonida studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kleineidamluca studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT knopmandavids studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kochannicolea studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kontebettina studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kwokjohnb studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lehellardstephanie studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT leeteresa studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lehtimakiterho studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lishuchen studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lillchristinam studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT liutian studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT koinimarisa studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT londonedythe studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT longstrethwillt studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lopezoscarl studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT loukolaanu studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lucktobias studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lundervoldastrij studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lundquistanders studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lyytikainenleopekka studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT martinnicholasg studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT montgomerygrantw studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT murrayalisond studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT needannac studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT noordamraymond studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT nyberglars studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT ollierwilliam studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT papenberggoran studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT pattiealison studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT polasekozren studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT poldrackrussella studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT psatybrucem studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT reppermundsimone studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT riedelhellersteffig studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT roserichardj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT rotterjeromei studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT roussospanos studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT roviosuvip studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT sabayasaman studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT sabbfredw studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT sachdevperminders studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT satizabalclaudial studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT schmidmatthias studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT scottrodneyj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT scultmatthewa studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT siminojeannette studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT slagboompeline studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT smyrnisnikolaos studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT soumareaicha studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT stefanisnikosc studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT stottdavidj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT straubricharde studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT sundetkjetil studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT tayloradelem studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT taylorkentd studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT tzoulakiioanna studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT tzouriochristophe studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT uitterlindenandre studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT vitartveronique studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT voineskosaristotlen studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kapriojaakko studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wagnermichael studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wagnerholger studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT weinholdleonie studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wenkhoyan studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT widenelisabeth studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT yangqiong studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT zhaowei studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT adamshieabhh studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT arkingdane studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT bilderrobertm studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT bitsiospanos studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT boerwinkleeric studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT chibafalekornit studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT corvinaiden studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT dejagerphilipl studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT debettestephanie studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT donohoegary studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT elliottpaul studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT fitzpatrickannettel studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT gillmichael studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT glahndavidc studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT haggsara studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT hansellnarellek studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT haririahmadr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT ikrammkamran studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT jukemajwouter studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT vuoksimaaeero studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kellermatthewc studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT kremenwilliams studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT launerlenore studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lindenbergerulman studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT palotieaarno studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT pedersennancyl studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT pendletonneil studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT porteousdavidj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT raikkonenkatri studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT raitakariollit studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT ramirezalfredo studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT reinvangivar studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT rudanigor studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT danrujescu studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT schmidtreinhold studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT schmidthelena studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT schofieldpeterw studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT schofieldpeterr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT starrjohnm studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT steenvidarm studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT trollorjuliann studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT turnerstevent studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT vanduijncorneliam studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT villringerarno studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT weinbergerdanielr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT weirdavidr studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT wilsonjamesf studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT malhotraanil studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT mcintoshandrewm studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT galecathariner studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT seshadrisudha studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT mosleythomash studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT bresslerjan studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT lencztodd studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction AT dearyianj studyof300486individualsidentifies148independentgeneticlociinfluencinggeneralcognitivefunction |