The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

R2TP is an HSP90 co-chaperone that assembles important macro-molecular machineries. It is composed of an RPAP3-PIH1D1 heterodimer, which binds the two essential AAA+ATPases RUVBL1/RUVBL2. Here, we resolve the structure of the conserved C-terminal domain of RPAP3, and we show that it directly binds R...

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Detalles Bibliográficos
Autores principales: Maurizy, Chloé, Quinternet, Marc, Abel, Yoann, Verheggen, Céline, Santo, Paulo E., Bourguet, Maxime, C.F. Paiva, Ana, Bragantini, Benoît, Chagot, Marie-Eve, Robert, Marie-Cécile, Abeza, Claire, Fabre, Philippe, Fort, Philippe, Vandermoere, Franck, M.F. Sousa, Pedro, Rain, Jean-Christophe, Charpentier, Bruno, Cianférani, Sarah, Bandeiras, Tiago M., Pradet-Balade, Bérengère, Manival, Xavier, Bertrand, Edouard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974087/
https://www.ncbi.nlm.nih.gov/pubmed/29844425
http://dx.doi.org/10.1038/s41467-018-04431-1

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