A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-based assay that specifically probes for ligands targeting the recently discovered maytansine site of tubulin. Using this as...

Descripción completa

Detalles Bibliográficos
Autores principales: Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974090/
https://www.ncbi.nlm.nih.gov/pubmed/29844393
http://dx.doi.org/10.1038/s41467-018-04535-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974090/
https://www.ncbi.nlm.nih.gov/pubmed/29844393
http://dx.doi.org/10.1038/s41467-018-04535-8

Ejemplares similares