Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes

Type 1 diabetes is caused by autoreactive T cell-mediated β cell destruction. Even though co-inhibitory receptor programmed death-1 (PD-1) restrains autoimmunity, the expression and regulation of its cognate ligands on β cell remains unknown. Here, we interrogated β cell-intrinsic programmed death l...

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Detalles Bibliográficos
Autores principales: Osum, Kevin C., Burrack, Adam L., Martinov, Tijana, Sahli, Nathanael L., Mitchell, Jason S., Tucker, Christopher G., Pauken, Kristen E., Papas, Klearchos, Appakalai, Balamurugan, Spanier, Justin A., Fife, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974126/
https://www.ncbi.nlm.nih.gov/pubmed/29844327
http://dx.doi.org/10.1038/s41598-018-26471-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974126/
https://www.ncbi.nlm.nih.gov/pubmed/29844327
http://dx.doi.org/10.1038/s41598-018-26471-9

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