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Lipid Droplet, a Key Player in Host-Parasite Interactions

Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated and may vary according to the stimuli, cell t...

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Autores principales: Vallochi, Adriana Lima, Teixeira, Livia, Oliveira, Karina da Silva, Maya-Monteiro, Clarissa Menezes, Bozza, Patricia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974170/
https://www.ncbi.nlm.nih.gov/pubmed/29875768
http://dx.doi.org/10.3389/fimmu.2018.01022
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author Vallochi, Adriana Lima
Teixeira, Livia
Oliveira, Karina da Silva
Maya-Monteiro, Clarissa Menezes
Bozza, Patricia T.
author_facet Vallochi, Adriana Lima
Teixeira, Livia
Oliveira, Karina da Silva
Maya-Monteiro, Clarissa Menezes
Bozza, Patricia T.
author_sort Vallochi, Adriana Lima
collection PubMed
description Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated and may vary according to the stimuli, cell type, activation state, and inflammatory environment. Increased cytoplasmic LDs are frequently observed in leukocytes and other cells in a number of infectious diseases. Accumulating evidence reveals LDs participation in fundamental mechanisms of host-pathogen interactions, including cell signaling and immunity. LDs are sources of eicosanoid production, and may participate in different aspects of innate signaling and antigen presentation. In addition, intracellular pathogens evolved mechanisms to subvert host metabolism and may use host LDs, as ways of immune evasion and nutrients source. Here, we review mechanisms of LDs biogenesis and their contributions to the infection progress, and discuss the latest discoveries on mechanisms and pathways involving LDs roles as regulators of the immune response to protozoan infection.
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spelling pubmed-59741702018-06-06 Lipid Droplet, a Key Player in Host-Parasite Interactions Vallochi, Adriana Lima Teixeira, Livia Oliveira, Karina da Silva Maya-Monteiro, Clarissa Menezes Bozza, Patricia T. Front Immunol Immunology Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated and may vary according to the stimuli, cell type, activation state, and inflammatory environment. Increased cytoplasmic LDs are frequently observed in leukocytes and other cells in a number of infectious diseases. Accumulating evidence reveals LDs participation in fundamental mechanisms of host-pathogen interactions, including cell signaling and immunity. LDs are sources of eicosanoid production, and may participate in different aspects of innate signaling and antigen presentation. In addition, intracellular pathogens evolved mechanisms to subvert host metabolism and may use host LDs, as ways of immune evasion and nutrients source. Here, we review mechanisms of LDs biogenesis and their contributions to the infection progress, and discuss the latest discoveries on mechanisms and pathways involving LDs roles as regulators of the immune response to protozoan infection. Frontiers Media S.A. 2018-05-23 /pmc/articles/PMC5974170/ /pubmed/29875768 http://dx.doi.org/10.3389/fimmu.2018.01022 Text en Copyright © 2018 Vallochi, Teixeira, Oliveira, Maya-Monteiro and Bozza. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Vallochi, Adriana Lima
Teixeira, Livia
Oliveira, Karina da Silva
Maya-Monteiro, Clarissa Menezes
Bozza, Patricia T.
Lipid Droplet, a Key Player in Host-Parasite Interactions
title Lipid Droplet, a Key Player in Host-Parasite Interactions
title_full Lipid Droplet, a Key Player in Host-Parasite Interactions
title_fullStr Lipid Droplet, a Key Player in Host-Parasite Interactions
title_full_unstemmed Lipid Droplet, a Key Player in Host-Parasite Interactions
title_short Lipid Droplet, a Key Player in Host-Parasite Interactions
title_sort lipid droplet, a key player in host-parasite interactions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974170/
https://www.ncbi.nlm.nih.gov/pubmed/29875768
http://dx.doi.org/10.3389/fimmu.2018.01022
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