Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly...

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Detalles Bibliográficos
Autores principales: Kovač, Kristina, Sauer, Anja, Mačinković, Igor, Awe, Stephan, Finkernagel, Florian, Hoffmeister, Helen, Fuchs, Andreas, Müller, Rolf, Rathke, Christina, Längst, Gernot, Brehm, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974244/
https://www.ncbi.nlm.nih.gov/pubmed/29844320
http://dx.doi.org/10.1038/s41467-018-04503-2

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