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Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study
The aim was to evaluate the efficacy and safety of different combination strategies for prophylaxis of venous thromboembolism (VTE) after gynecologic surgery in patients at different levels of risk. This was a prospective multicenter randomized controlled study, in which 625 women who would undergo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974317/ https://www.ncbi.nlm.nih.gov/pubmed/29844423 http://dx.doi.org/10.1038/s41598-018-25274-2 |
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author | Sang, Cui-Qin Zhao, Na Zhang, Jian Wang, Shu-Zhen Guo, Shu-Li Li, Shu-Hong Jiang, Ying Li, Bin Wang, Jian-Liu Song, Lei Zhai, Jian-Jun Zhang, Zhen-Yu |
author_facet | Sang, Cui-Qin Zhao, Na Zhang, Jian Wang, Shu-Zhen Guo, Shu-Li Li, Shu-Hong Jiang, Ying Li, Bin Wang, Jian-Liu Song, Lei Zhai, Jian-Jun Zhang, Zhen-Yu |
author_sort | Sang, Cui-Qin |
collection | PubMed |
description | The aim was to evaluate the efficacy and safety of different combination strategies for prophylaxis of venous thromboembolism (VTE) after gynecologic surgery in patients at different levels of risk. This was a prospective multicenter randomized controlled study, in which 625 women who would undergo pelvic surgery for gynecologic diseases were stratified into three risk groups and then randomized into four groups to receive graduated compression stockings (GCS) alone (group A), GCS + low molecular weight heparin (LMWH) (group B), GCS + intermittent pneumatic compression (IPC) (group C), and GCS + IPC + LMWH (group C), respectively. The overall incidence of DVT was 5.1%. Group A had the highest incidence of DVT (8.8%), followed by group C (5.2%), group B (3.8%), and group D (2.6%). There was a significant difference in the incidence of DVT between groups A and D. The incidence of DVT was significantly lower in LMWH-treated patients (group B + group D) than in non-LMWH-treated patients (group A + group C). In conclusion, combination prophylaxis, especially LMWH-containing strategies, is better than monoprophylaxis in reducing VTE after gynecologic surgery. Risk-stratified prophylactic strategies should be implemented in patients undergoing gynecologic surgery, with LMWH-containing strategies being recommended for high-risk and very-high-risk patients. |
format | Online Article Text |
id | pubmed-5974317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59743172018-05-31 Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study Sang, Cui-Qin Zhao, Na Zhang, Jian Wang, Shu-Zhen Guo, Shu-Li Li, Shu-Hong Jiang, Ying Li, Bin Wang, Jian-Liu Song, Lei Zhai, Jian-Jun Zhang, Zhen-Yu Sci Rep Article The aim was to evaluate the efficacy and safety of different combination strategies for prophylaxis of venous thromboembolism (VTE) after gynecologic surgery in patients at different levels of risk. This was a prospective multicenter randomized controlled study, in which 625 women who would undergo pelvic surgery for gynecologic diseases were stratified into three risk groups and then randomized into four groups to receive graduated compression stockings (GCS) alone (group A), GCS + low molecular weight heparin (LMWH) (group B), GCS + intermittent pneumatic compression (IPC) (group C), and GCS + IPC + LMWH (group C), respectively. The overall incidence of DVT was 5.1%. Group A had the highest incidence of DVT (8.8%), followed by group C (5.2%), group B (3.8%), and group D (2.6%). There was a significant difference in the incidence of DVT between groups A and D. The incidence of DVT was significantly lower in LMWH-treated patients (group B + group D) than in non-LMWH-treated patients (group A + group C). In conclusion, combination prophylaxis, especially LMWH-containing strategies, is better than monoprophylaxis in reducing VTE after gynecologic surgery. Risk-stratified prophylactic strategies should be implemented in patients undergoing gynecologic surgery, with LMWH-containing strategies being recommended for high-risk and very-high-risk patients. Nature Publishing Group UK 2018-05-29 /pmc/articles/PMC5974317/ /pubmed/29844423 http://dx.doi.org/10.1038/s41598-018-25274-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sang, Cui-Qin Zhao, Na Zhang, Jian Wang, Shu-Zhen Guo, Shu-Li Li, Shu-Hong Jiang, Ying Li, Bin Wang, Jian-Liu Song, Lei Zhai, Jian-Jun Zhang, Zhen-Yu Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title | Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title_full | Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title_fullStr | Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title_full_unstemmed | Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title_short | Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicenter randomized controlled study |
title_sort | different combination strategies for prophylaxis of venous thromboembolism in patients: a prospective multicenter randomized controlled study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974317/ https://www.ncbi.nlm.nih.gov/pubmed/29844423 http://dx.doi.org/10.1038/s41598-018-25274-2 |
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