mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T(reg) subsets to protect tissue homeostasis

Regulatory T (T(reg)) cells derived from the thymus (tT(reg)) and periphery (pT(reg)) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of T(reg) subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpected...

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Detalles Bibliográficos
Autores principales: Chapman, Nicole M., Zeng, Hu, Nguyen, Thanh-Long M., Wang, Yanyan, Vogel, Peter, Dhungana, Yogesh, Liu, Xiaojing, Neale, Geoffrey, Locasale, Jason W., Chi, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974344/
https://www.ncbi.nlm.nih.gov/pubmed/29844370
http://dx.doi.org/10.1038/s41467-018-04392-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974344/
https://www.ncbi.nlm.nih.gov/pubmed/29844370
http://dx.doi.org/10.1038/s41467-018-04392-5

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