The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion

TIN2 is central to the shelterin complex, linking the telomeric proteins TRF1 and TRF2 with TPP1/POT1. Mutations in TINF2, which encodes TIN2, that are found in dyskeratosis congenita (DC) result in very short telomeres and cluster in a region shared by the two TIN2 isoforms, TIN2S (short) and TIN2L...

Descripción completa

Detalles Bibliográficos
Autores principales: Nelson, Nya D., Dodson, Lois M., Escudero, Laura, Sukumar, Ann T., Williams, Christopher L., Mihalek, Ivana, Baldan, Alessandro, Baird, Duncan M., Bertuch, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974431/
https://www.ncbi.nlm.nih.gov/pubmed/29581185
http://dx.doi.org/10.1128/MCB.00025-18

Ejemplares similares

Ejemplares similares