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Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies

Vaccines that elicit broadly neutralizing antibodies to the conserved stem of hemagglutinin (HA) are being developed as universal influenza vaccines that protect against influenza across multiple years. However, different influenza virus strains, even those in the same subtype with identical stem se...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Song, Hyo Sook, Keller, Paul W., Alvarado-Facundo, Esmeralda, Vassell, Russell, Weiss, Carol D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974491/
https://www.ncbi.nlm.nih.gov/pubmed/29593038
http://dx.doi.org/10.1128/JVI.00247-18