Cargando…

High‐throughput discovery of functional disordered regions

Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Muhammad, Ivarsson, Ylva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974509/
https://www.ncbi.nlm.nih.gov/pubmed/29789308
http://dx.doi.org/10.15252/msb.20188377
_version_ 1783326825483599872
author Ali, Muhammad
Ivarsson, Ylva
author_facet Ali, Muhammad
Ivarsson, Ylva
author_sort Ali, Muhammad
collection PubMed
description Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al, 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions.
format Online
Article
Text
id pubmed-5974509
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-59745092018-06-05 High‐throughput discovery of functional disordered regions Ali, Muhammad Ivarsson, Ylva Mol Syst Biol News & Views Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al, 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions. John Wiley and Sons Inc. 2018-05-22 /pmc/articles/PMC5974509/ /pubmed/29789308 http://dx.doi.org/10.15252/msb.20188377 Text en © 2018 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Ali, Muhammad
Ivarsson, Ylva
High‐throughput discovery of functional disordered regions
title High‐throughput discovery of functional disordered regions
title_full High‐throughput discovery of functional disordered regions
title_fullStr High‐throughput discovery of functional disordered regions
title_full_unstemmed High‐throughput discovery of functional disordered regions
title_short High‐throughput discovery of functional disordered regions
title_sort high‐throughput discovery of functional disordered regions
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974509/
https://www.ncbi.nlm.nih.gov/pubmed/29789308
http://dx.doi.org/10.15252/msb.20188377
work_keys_str_mv AT alimuhammad highthroughputdiscoveryoffunctionaldisorderedregions
AT ivarssonylva highthroughputdiscoveryoffunctionaldisorderedregions