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High‐throughput discovery of functional disordered regions
Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974509/ https://www.ncbi.nlm.nih.gov/pubmed/29789308 http://dx.doi.org/10.15252/msb.20188377 |
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author | Ali, Muhammad Ivarsson, Ylva |
author_facet | Ali, Muhammad Ivarsson, Ylva |
author_sort | Ali, Muhammad |
collection | PubMed |
description | Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al, 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions. |
format | Online Article Text |
id | pubmed-5974509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59745092018-06-05 High‐throughput discovery of functional disordered regions Ali, Muhammad Ivarsson, Ylva Mol Syst Biol News & Views Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al, 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions. John Wiley and Sons Inc. 2018-05-22 /pmc/articles/PMC5974509/ /pubmed/29789308 http://dx.doi.org/10.15252/msb.20188377 Text en © 2018 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | News & Views Ali, Muhammad Ivarsson, Ylva High‐throughput discovery of functional disordered regions |
title | High‐throughput discovery of functional disordered regions |
title_full | High‐throughput discovery of functional disordered regions |
title_fullStr | High‐throughput discovery of functional disordered regions |
title_full_unstemmed | High‐throughput discovery of functional disordered regions |
title_short | High‐throughput discovery of functional disordered regions |
title_sort | high‐throughput discovery of functional disordered regions |
topic | News & Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974509/ https://www.ncbi.nlm.nih.gov/pubmed/29789308 http://dx.doi.org/10.15252/msb.20188377 |
work_keys_str_mv | AT alimuhammad highthroughputdiscoveryoffunctionaldisorderedregions AT ivarssonylva highthroughputdiscoveryoffunctionaldisorderedregions |