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Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying thi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974614/ https://www.ncbi.nlm.nih.gov/pubmed/29665671 http://dx.doi.org/10.14348/molcells.2018.0081 |
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author | Park, Dongseok Bae, Sungwon Yoon, Taek Han Ko, Jaewon |
author_facet | Park, Dongseok Bae, Sungwon Yoon, Taek Han Ko, Jaewon |
author_sort | Park, Dongseok |
collection | PubMed |
description | Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum. |
format | Online Article Text |
id | pubmed-5974614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-59746142018-06-13 Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers Park, Dongseok Bae, Sungwon Yoon, Taek Han Ko, Jaewon Mol Cells Minireview Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum. Korean Society for Molecular and Cellular Biology 2018-05-31 2018-04-18 /pmc/articles/PMC5974614/ /pubmed/29665671 http://dx.doi.org/10.14348/molcells.2018.0081 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. |
spellingShingle | Minireview Park, Dongseok Bae, Sungwon Yoon, Taek Han Ko, Jaewon Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title | Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title_full | Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title_fullStr | Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title_full_unstemmed | Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title_short | Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers |
title_sort | molecular mechanisms of synaptic specificity: spotlight on hippocampal and cerebellar synapse organizers |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974614/ https://www.ncbi.nlm.nih.gov/pubmed/29665671 http://dx.doi.org/10.14348/molcells.2018.0081 |
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