Cargando…

Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers

Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Dongseok, Bae, Sungwon, Yoon, Taek Han, Ko, Jaewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974614/
https://www.ncbi.nlm.nih.gov/pubmed/29665671
http://dx.doi.org/10.14348/molcells.2018.0081
_version_ 1783326848928710656
author Park, Dongseok
Bae, Sungwon
Yoon, Taek Han
Ko, Jaewon
author_facet Park, Dongseok
Bae, Sungwon
Yoon, Taek Han
Ko, Jaewon
author_sort Park, Dongseok
collection PubMed
description Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.
format Online
Article
Text
id pubmed-5974614
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Korean Society for Molecular and Cellular Biology
record_format MEDLINE/PubMed
spelling pubmed-59746142018-06-13 Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers Park, Dongseok Bae, Sungwon Yoon, Taek Han Ko, Jaewon Mol Cells Minireview Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum. Korean Society for Molecular and Cellular Biology 2018-05-31 2018-04-18 /pmc/articles/PMC5974614/ /pubmed/29665671 http://dx.doi.org/10.14348/molcells.2018.0081 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Park, Dongseok
Bae, Sungwon
Yoon, Taek Han
Ko, Jaewon
Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title_full Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title_fullStr Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title_full_unstemmed Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title_short Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
title_sort molecular mechanisms of synaptic specificity: spotlight on hippocampal and cerebellar synapse organizers
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974614/
https://www.ncbi.nlm.nih.gov/pubmed/29665671
http://dx.doi.org/10.14348/molcells.2018.0081
work_keys_str_mv AT parkdongseok molecularmechanismsofsynapticspecificityspotlightonhippocampalandcerebellarsynapseorganizers
AT baesungwon molecularmechanismsofsynapticspecificityspotlightonhippocampalandcerebellarsynapseorganizers
AT yoontaekhan molecularmechanismsofsynapticspecificityspotlightonhippocampalandcerebellarsynapseorganizers
AT kojaewon molecularmechanismsofsynapticspecificityspotlightonhippocampalandcerebellarsynapseorganizers