AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway

Aberrations in histone modifications are being studied in mixed-lineage leukemia (MLL)-AF9-driven acute myeloid leukemia (AML). In this study, we focused on the regulation of the differentiation of the MLL-AF9 type AML cell line THP-1. We observed that, upon phorbol 12-myristate 13-acetate (PMA) tre...

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Detalles Bibliográficos
Autores principales: Park, Jin Woo, Cho, Hana, Oh, Hyein, Kim, Ji-Young, Seo, Sang-Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974621/
https://www.ncbi.nlm.nih.gov/pubmed/29477140
http://dx.doi.org/10.14348/molcells.2018.2311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974621/
https://www.ncbi.nlm.nih.gov/pubmed/29477140
http://dx.doi.org/10.14348/molcells.2018.2311

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