Cargando…
Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia
Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruse...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974707/ https://www.ncbi.nlm.nih.gov/pubmed/29868164 http://dx.doi.org/10.1080/20002297.2018.1476643 |
_version_ | 1783326870257795072 |
---|---|
author | Palmieri, Michelle Ornaghi, Mariana Martins, Victor Adriano de Oliveira Correa, Luciana Brandao, Thais Bianca Ribeiro, Ana Carolina do Prado Sumita, Laura Masami Tozetto-Mendoza, Tania Regina Pannuti, Claudio Sergio Braz-Silva, Paulo Henrique |
author_facet | Palmieri, Michelle Ornaghi, Mariana Martins, Victor Adriano de Oliveira Correa, Luciana Brandao, Thais Bianca Ribeiro, Ana Carolina do Prado Sumita, Laura Masami Tozetto-Mendoza, Tania Regina Pannuti, Claudio Sergio Braz-Silva, Paulo Henrique |
author_sort | Palmieri, Michelle |
collection | PubMed |
description | Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods: In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy. The samples were submitted to PCR and enzymatic digestion for detection of human herpesviruses. Xerostomia was evaluated according to the Seminars in Radiation Oncology criteria. Results: There was a higher frequency of grade 1 xerostomia (51.4%), observed first in the 1st week of radiotherapy. In the 4th week of radiotherapy, all patients presented some degree of xerostomia. Analysis of herpesviruses showed oral shedding of EBV, HHV-6 and HHV-7 in all weeks. Considering all the periods, the highest frequency was in patients with EBV excretion (55.0%), which was significantly higher than that of other viruses. Conclusion: We observed that oral shedding of herpesviruses was not affected by xerostomia as there was a progression in their excretion, even with the evolution of xerostomia. This suggested that there is a local replication in the oral cavity that is not completely dependent of salivary excretion. |
format | Online Article Text |
id | pubmed-5974707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-59747072018-06-04 Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia Palmieri, Michelle Ornaghi, Mariana Martins, Victor Adriano de Oliveira Correa, Luciana Brandao, Thais Bianca Ribeiro, Ana Carolina do Prado Sumita, Laura Masami Tozetto-Mendoza, Tania Regina Pannuti, Claudio Sergio Braz-Silva, Paulo Henrique J Oral Microbiol Original Article Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods: In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy. The samples were submitted to PCR and enzymatic digestion for detection of human herpesviruses. Xerostomia was evaluated according to the Seminars in Radiation Oncology criteria. Results: There was a higher frequency of grade 1 xerostomia (51.4%), observed first in the 1st week of radiotherapy. In the 4th week of radiotherapy, all patients presented some degree of xerostomia. Analysis of herpesviruses showed oral shedding of EBV, HHV-6 and HHV-7 in all weeks. Considering all the periods, the highest frequency was in patients with EBV excretion (55.0%), which was significantly higher than that of other viruses. Conclusion: We observed that oral shedding of herpesviruses was not affected by xerostomia as there was a progression in their excretion, even with the evolution of xerostomia. This suggested that there is a local replication in the oral cavity that is not completely dependent of salivary excretion. Taylor & Francis 2018-05-28 /pmc/articles/PMC5974707/ /pubmed/29868164 http://dx.doi.org/10.1080/20002297.2018.1476643 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Palmieri, Michelle Ornaghi, Mariana Martins, Victor Adriano de Oliveira Correa, Luciana Brandao, Thais Bianca Ribeiro, Ana Carolina do Prado Sumita, Laura Masami Tozetto-Mendoza, Tania Regina Pannuti, Claudio Sergio Braz-Silva, Paulo Henrique Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title | Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title_full | Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title_fullStr | Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title_full_unstemmed | Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title_short | Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
title_sort | oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974707/ https://www.ncbi.nlm.nih.gov/pubmed/29868164 http://dx.doi.org/10.1080/20002297.2018.1476643 |
work_keys_str_mv | AT palmierimichelle oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT ornaghimariana oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT martinsvictoradrianodeoliveira oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT correaluciana oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT brandaothaisbianca oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT ribeiroanacarolinadoprado oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT sumitalauramasami oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT tozettomendozataniaregina oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT pannuticlaudiosergio oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia AT brazsilvapaulohenrique oralsheddingofhumanherpesvirusesinpatientsundergoingradiotherapychemotherapyforheadandnecksquamouscellcarcinomaisnotaffectedbyxerostomia |