Editorial Focus: CFTR‐dependent bicarbonate secretion by Calu‐3 cells

Cystic Fibrosis is an autosomal recessive multisystem disease caused by the severely impaired or absent function of the Cystic Fibrosis Transmembrane Conductance Regulator, CFTR. While CFTR is best recognized as a Cl‐ channel, impairment of CFTR‐dependent bicarbonate transport is increasingly recognized as a potentially key element in the pathophysiology of airways disease in CF. It is in this context that the discussed in this Editorial Focus by Huang, Kim, et al. has significant relevance to CF and our understanding of the pathophysiology of CF airway.