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Cell Cycle Dynamics of the Nuclear Envelope

The nuclear envelope (NE) consists of an inner and an outer membrane, nuclear pore complexes, and the underlying nuclear lamina, a filamentous scaffold structure formed by lamins. The inner membrane is linked to the lamina and chromatin by its integral membrane proteins, such as lamin B receptor (LB...

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Autor principal: Foisner, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974750/
https://www.ncbi.nlm.nih.gov/pubmed/12806116
http://dx.doi.org/10.1100/tsw.2003.06
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author Foisner, Roland
author_facet Foisner, Roland
author_sort Foisner, Roland
collection PubMed
description The nuclear envelope (NE) consists of an inner and an outer membrane, nuclear pore complexes, and the underlying nuclear lamina, a filamentous scaffold structure formed by lamins. The inner membrane is linked to the lamina and chromatin by its integral membrane proteins, such as lamin B receptor (LBR), emerin, and various isoforms of lamina-associated polypeptides (LAP) 1 and 2, which bind lamins and/or chromatin. During mitosis, the NE is disassembled upon phosphorylation of its core components, and the NE is torn apart by a dynein-driven microtubule-dependent mechanism. Nuclear reassembly after sister chromatid separation requires a timely coordinated and dephosphorylation-dependent association of lamin-binding proteins and lamins with chromosomal proteins and targeting of membranes to specific sites on chromosomes. Various chromatin-binding domains in lamina proteins, such as the LEM domain, present in all LAP2 isoforms and in emerin, as well as unique regions in lamina proteins and in specific LAP2 isoforms have been implicated in defined steps of NE reformation. Furthermore, novel mechanisms of membrane fusion involving Ran GTPase are just beginning to emerge.
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spelling pubmed-59747502018-06-10 Cell Cycle Dynamics of the Nuclear Envelope Foisner, Roland ScientificWorldJournal Mini-Review Article The nuclear envelope (NE) consists of an inner and an outer membrane, nuclear pore complexes, and the underlying nuclear lamina, a filamentous scaffold structure formed by lamins. The inner membrane is linked to the lamina and chromatin by its integral membrane proteins, such as lamin B receptor (LBR), emerin, and various isoforms of lamina-associated polypeptides (LAP) 1 and 2, which bind lamins and/or chromatin. During mitosis, the NE is disassembled upon phosphorylation of its core components, and the NE is torn apart by a dynein-driven microtubule-dependent mechanism. Nuclear reassembly after sister chromatid separation requires a timely coordinated and dephosphorylation-dependent association of lamin-binding proteins and lamins with chromosomal proteins and targeting of membranes to specific sites on chromosomes. Various chromatin-binding domains in lamina proteins, such as the LEM domain, present in all LAP2 isoforms and in emerin, as well as unique regions in lamina proteins and in specific LAP2 isoforms have been implicated in defined steps of NE reformation. Furthermore, novel mechanisms of membrane fusion involving Ran GTPase are just beginning to emerge. TheScientificWorldJOURNAL 2003-03-17 /pmc/articles/PMC5974750/ /pubmed/12806116 http://dx.doi.org/10.1100/tsw.2003.06 Text en Copyright © 2003 Roland Foisner. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Foisner, Roland
Cell Cycle Dynamics of the Nuclear Envelope
title Cell Cycle Dynamics of the Nuclear Envelope
title_full Cell Cycle Dynamics of the Nuclear Envelope
title_fullStr Cell Cycle Dynamics of the Nuclear Envelope
title_full_unstemmed Cell Cycle Dynamics of the Nuclear Envelope
title_short Cell Cycle Dynamics of the Nuclear Envelope
title_sort cell cycle dynamics of the nuclear envelope
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974750/
https://www.ncbi.nlm.nih.gov/pubmed/12806116
http://dx.doi.org/10.1100/tsw.2003.06
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