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Structural Models for Cytochrome P450—Mediated Catalysis

This review focuses on the structural models for cytochrome P450 that are improving our knowledge and understanding of the P450 catalytic cycle, and the way in which substrates bind to the enzyme leading to catalytic conversion and subsequent formation of mono-oxygenated metabolites. Various stages...

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Autor principal: Lewis, David F.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974764/
https://www.ncbi.nlm.nih.gov/pubmed/12847303
http://dx.doi.org/10.1100/tsw.2003.41
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author Lewis, David F.V.
author_facet Lewis, David F.V.
author_sort Lewis, David F.V.
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description This review focuses on the structural models for cytochrome P450 that are improving our knowledge and understanding of the P450 catalytic cycle, and the way in which substrates bind to the enzyme leading to catalytic conversion and subsequent formation of mono-oxygenated metabolites. Various stages in the P450 reaction cycle have now been investigated using X-ray crystallography and electronic structure calculations, whereas homology modelling of mammalian P450s is currently revealing important aspects of pharmaceutical and other xenobiotic metabolism mediated by P450 involvement. These features are explored in the current review on P450-based catalysis, which emphasises the importance of structural modelling to our understanding of this enzyme's function. In addition, the results of various QSAR analyses on series of chemicals, which are metabolised via P450 enzymes, are presented such that the importance of electronic and other structural factors in explaining variations in rates of metabolism can be appreciated.
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spelling pubmed-59747642018-06-10 Structural Models for Cytochrome P450—Mediated Catalysis Lewis, David F.V. ScientificWorldJournal Review Article This review focuses on the structural models for cytochrome P450 that are improving our knowledge and understanding of the P450 catalytic cycle, and the way in which substrates bind to the enzyme leading to catalytic conversion and subsequent formation of mono-oxygenated metabolites. Various stages in the P450 reaction cycle have now been investigated using X-ray crystallography and electronic structure calculations, whereas homology modelling of mammalian P450s is currently revealing important aspects of pharmaceutical and other xenobiotic metabolism mediated by P450 involvement. These features are explored in the current review on P450-based catalysis, which emphasises the importance of structural modelling to our understanding of this enzyme's function. In addition, the results of various QSAR analyses on series of chemicals, which are metabolised via P450 enzymes, are presented such that the importance of electronic and other structural factors in explaining variations in rates of metabolism can be appreciated. TheScientificWorldJOURNAL 2003-06-20 /pmc/articles/PMC5974764/ /pubmed/12847303 http://dx.doi.org/10.1100/tsw.2003.41 Text en Copyright © 2003 David F.V. Lewis. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lewis, David F.V.
Structural Models for Cytochrome P450—Mediated Catalysis
title Structural Models for Cytochrome P450—Mediated Catalysis
title_full Structural Models for Cytochrome P450—Mediated Catalysis
title_fullStr Structural Models for Cytochrome P450—Mediated Catalysis
title_full_unstemmed Structural Models for Cytochrome P450—Mediated Catalysis
title_short Structural Models for Cytochrome P450—Mediated Catalysis
title_sort structural models for cytochrome p450—mediated catalysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974764/
https://www.ncbi.nlm.nih.gov/pubmed/12847303
http://dx.doi.org/10.1100/tsw.2003.41
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