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Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development

Craniofacial development is an extraordinarily complex process requiring the orchestrated integration of multiple specialized tissues such as the surface ectoderm, neural crest, mesoderm, and pharyngeal endoderm in order to generate the central and peripheral nervous systems, axial skeleton, muscula...

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Autor principal: Trainor, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974867/
https://www.ncbi.nlm.nih.gov/pubmed/12806110
http://dx.doi.org/10.1100/tsw.2003.11
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author Trainor, Paul A.
author_facet Trainor, Paul A.
author_sort Trainor, Paul A.
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description Craniofacial development is an extraordinarily complex process requiring the orchestrated integration of multiple specialized tissues such as the surface ectoderm, neural crest, mesoderm, and pharyngeal endoderm in order to generate the central and peripheral nervous systems, axial skeleton, musculature, and connective tissues of the head and face. How do the characteristic facial structures develop in the appropriate locations with their correct shapes and sizes, given the widely divergent patterns of cell movements that occur during head development? The patterning information could depend upon localized interactions between the epithelial and mesenchymal tissues or alternatively, the developmental program for the characteristic facial structures could be intrinsic to each individual tissue precursor. Understanding the mechanisms that control vertebrate head development is an important issue since craniofacial anomalies constitute nearly one third of all human congenital defects. This review discusses recent advances in our understanding of neural crest cell patterning and the dynamic nature of the tissue interactions that are required for normal craniofacial development.
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spelling pubmed-59748672018-06-10 Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development Trainor, Paul A. ScientificWorldJournal Mini-Review Article Craniofacial development is an extraordinarily complex process requiring the orchestrated integration of multiple specialized tissues such as the surface ectoderm, neural crest, mesoderm, and pharyngeal endoderm in order to generate the central and peripheral nervous systems, axial skeleton, musculature, and connective tissues of the head and face. How do the characteristic facial structures develop in the appropriate locations with their correct shapes and sizes, given the widely divergent patterns of cell movements that occur during head development? The patterning information could depend upon localized interactions between the epithelial and mesenchymal tissues or alternatively, the developmental program for the characteristic facial structures could be intrinsic to each individual tissue precursor. Understanding the mechanisms that control vertebrate head development is an important issue since craniofacial anomalies constitute nearly one third of all human congenital defects. This review discusses recent advances in our understanding of neural crest cell patterning and the dynamic nature of the tissue interactions that are required for normal craniofacial development. TheScientificWorldJOURNAL 2003-04-14 /pmc/articles/PMC5974867/ /pubmed/12806110 http://dx.doi.org/10.1100/tsw.2003.11 Text en Copyright © 2003 Paul A. Trainor. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Trainor, Paul A.
Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title_full Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title_fullStr Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title_full_unstemmed Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title_short Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
title_sort making headway: the roles of hox genes and neural crest cells in craniofacial development
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974867/
https://www.ncbi.nlm.nih.gov/pubmed/12806110
http://dx.doi.org/10.1100/tsw.2003.11
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