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The Use of Spreadsheets for Pharmacokinetic Simulations

The use of simple spreadsheets is described to create simulations of complex pharmacokinetic phenomena. The basics of spreadsheets are first described and are developed to demonstrate classical pharmacokinetics without the use of differential or integral calculus. Using standard spreadsheet commands...

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Detalles Bibliográficos
Autor principal: Chamberlain, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974879/
https://www.ncbi.nlm.nih.gov/pubmed/12806111
http://dx.doi.org/10.1100/tsw.2003.02
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author Chamberlain, Joseph
author_facet Chamberlain, Joseph
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description The use of simple spreadsheets is described to create simulations of complex pharmacokinetic phenomena. The basics of spreadsheets are first described and are developed to demonstrate classical pharmacokinetics without the use of differential or integral calculus. Using standard spreadsheet commands, the technique is shown to be applicable to the full range of advanced pharmacokinetic simulations. Demonstrations of the effect of a variety of physiological eventualities are included to show the versatility of the technique. The technique is very simple to use and is always in the complete control of the modeller.
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spelling pubmed-59748792018-06-10 The Use of Spreadsheets for Pharmacokinetic Simulations Chamberlain, Joseph ScientificWorldJournal Methods Paper The use of simple spreadsheets is described to create simulations of complex pharmacokinetic phenomena. The basics of spreadsheets are first described and are developed to demonstrate classical pharmacokinetics without the use of differential or integral calculus. Using standard spreadsheet commands, the technique is shown to be applicable to the full range of advanced pharmacokinetic simulations. Demonstrations of the effect of a variety of physiological eventualities are included to show the versatility of the technique. The technique is very simple to use and is always in the complete control of the modeller. TheScientificWorldJOURNAL 2003-04-21 /pmc/articles/PMC5974879/ /pubmed/12806111 http://dx.doi.org/10.1100/tsw.2003.02 Text en Copyright © 2003 Joseph Chamberlain. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methods Paper
Chamberlain, Joseph
The Use of Spreadsheets for Pharmacokinetic Simulations
title The Use of Spreadsheets for Pharmacokinetic Simulations
title_full The Use of Spreadsheets for Pharmacokinetic Simulations
title_fullStr The Use of Spreadsheets for Pharmacokinetic Simulations
title_full_unstemmed The Use of Spreadsheets for Pharmacokinetic Simulations
title_short The Use of Spreadsheets for Pharmacokinetic Simulations
title_sort use of spreadsheets for pharmacokinetic simulations
topic Methods Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974879/
https://www.ncbi.nlm.nih.gov/pubmed/12806111
http://dx.doi.org/10.1100/tsw.2003.02
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