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Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin
T and B cell interactions are thought to be of prime importance in the generation of a humoral immune response. These interactions are thought to take place in the secondary lymphoid organs. The largest of which is the spleen. While the pathways involved in lymphocyte migration into other secondary...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974887/ https://www.ncbi.nlm.nih.gov/pubmed/12847299 http://dx.doi.org/10.1100/tsw.2003.42 |
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author | Grayson, Mitchell H. Chaplin, David D. |
author_facet | Grayson, Mitchell H. Chaplin, David D. |
author_sort | Grayson, Mitchell H. |
collection | PubMed |
description | T and B cell interactions are thought to be of prime importance in the generation of a humoral immune response. These interactions are thought to take place in the secondary lymphoid organs. The largest of which is the spleen. While the pathways involved in lymphocyte migration into other secondary lymphoid organs have been unraveled, very little is understood about T and B cell migration to the spleen. We report that adoptively transferred T lymphocytes appear more rapidly within the lymphoid compartment of the spleen than do B lymphocytes. Indeed, half of the transferred T lymphocytes in the spleen appear within the white pulp by 1.4 hours. B lymphocytes take nearly 4.3 hours to achieve the same level of accumulation. In addition, T lymphocyte arrival is fucoidan sensitive, while B cells are not affected by this polysaccharide. Finally, we show that neither L-, E-, or P-selectin appears to play a significant role in the accumulation of lymphocytes in the white pulp.) |
format | Online Article Text |
id | pubmed-5974887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-59748872018-06-10 Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin Grayson, Mitchell H. Chaplin, David D. ScientificWorldJournal Research Article T and B cell interactions are thought to be of prime importance in the generation of a humoral immune response. These interactions are thought to take place in the secondary lymphoid organs. The largest of which is the spleen. While the pathways involved in lymphocyte migration into other secondary lymphoid organs have been unraveled, very little is understood about T and B cell migration to the spleen. We report that adoptively transferred T lymphocytes appear more rapidly within the lymphoid compartment of the spleen than do B lymphocytes. Indeed, half of the transferred T lymphocytes in the spleen appear within the white pulp by 1.4 hours. B lymphocytes take nearly 4.3 hours to achieve the same level of accumulation. In addition, T lymphocyte arrival is fucoidan sensitive, while B cells are not affected by this polysaccharide. Finally, we show that neither L-, E-, or P-selectin appears to play a significant role in the accumulation of lymphocytes in the white pulp.) TheScientificWorldJOURNAL 2003-06-09 /pmc/articles/PMC5974887/ /pubmed/12847299 http://dx.doi.org/10.1100/tsw.2003.42 Text en Copyright © 2003 Mitchell H. Grayson and David D. Chaplin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Grayson, Mitchell H. Chaplin, David D. Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title | Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title_full | Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title_fullStr | Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title_full_unstemmed | Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title_short | Localization of T and B Lymphocytes to the White Pulp of the Spleen is Independent of L-, E-, and P-Selectin |
title_sort | localization of t and b lymphocytes to the white pulp of the spleen is independent of l-, e-, and p-selectin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974887/ https://www.ncbi.nlm.nih.gov/pubmed/12847299 http://dx.doi.org/10.1100/tsw.2003.42 |
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