Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The object...

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Detalles Bibliográficos
Autores principales: DeGregorio-Rocasolano, Nuria, Martí-Sistac, Octavi, Ponce, Jovita, Castelló-Ruiz, María, Millán, Mònica, Guirao, Verónica, García-Yébenes, Isaac, Salom, Juan B., Ramos-Cabrer, Pedro, Alborch, Enrique, Lizasoain, Ignacio, Castillo, José, Dávalos, Antoni, Gasull, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975212/
https://www.ncbi.nlm.nih.gov/pubmed/29248829
http://dx.doi.org/10.1016/j.redox.2017.11.026

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