Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1(H46R)-expressing ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have shown that mutations in SQSTM1 are linked to ALS. SQSTM1 encodes SQSTM1/p62 that regulates not only autophagy via the association wit...

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Detalles Bibliográficos
Autores principales: Mitsui, Shun, Otomo, Asako, Nozaki, Masahisa, Ono, Suzuka, Sato, Kai, Shirakawa, Ryohei, Adachi, Hiroaki, Aoki, Masashi, Sobue, Gen, Shang, Hui-Fang, Hadano, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975400/
https://www.ncbi.nlm.nih.gov/pubmed/29843805
http://dx.doi.org/10.1186/s13041-018-0373-8

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