Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model

BACKGROUND: Adoptive cell transfer (ACT) is a promising cancer immunotherapeutic strategy that remains ineffective for a large subset of patients. ACT with memory CD8+ T cells (T(mem)) has been shown to have superior efficacy compared to traditional ACT with effector CD8+ T cells (T(eff)). T(eff) an...

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Detalles Bibliográficos
Autores principales: Contreras, Amanda, Beems, Megan V., Tatar, Andrew J., Sen, Siddhartha, Srinand, Prakrithi, Suresh, M., Luther, Tahra K., Cho, Clifford S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975512/
https://www.ncbi.nlm.nih.gov/pubmed/29843822
http://dx.doi.org/10.1186/s40425-018-0358-2

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