miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway

BACKGROUND: Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as a tumor suppressor in glioma by targeting the signal transducer and activator of transcription 3 (STAT3)-mediated autophagy oncogenic pathway....

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Detalles Bibliográficos
Autores principales: Li, Hong, Chen, Lei, Li, Jun-jie, Zhou, Qiang, Huang, Annie, Liu, Wei-wen, Wang, Ke, Gao, Liang, Qi, Song-tao, Lu, Yun-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975545/
https://www.ncbi.nlm.nih.gov/pubmed/29843746
http://dx.doi.org/10.1186/s13045-018-0618-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975545/
https://www.ncbi.nlm.nih.gov/pubmed/29843746
http://dx.doi.org/10.1186/s13045-018-0618-0

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