First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

BACKGROUND: Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax(®)-L) to standard therapy for newly diagnosed glioblastoma. METHODS: After surgery and chemorad...

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Detalles Bibliográficos
Autores principales: Liau, Linda M., Ashkan, Keyoumars, Tran, David D., Campian, Jian L., Trusheim, John E., Cobbs, Charles S., Heth, Jason A., Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D., Iwamoto, Fabio M., Dropcho, Edward J., Moshel, Yaron A., Walter, Kevin A., Pillainayagam, Clement P., Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A., Bota, Daniela A., Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A., Lillehei, Kevin O., Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R., Brenner, Andrew J., Brem, Steven, Ewend, Matthew G., Khagi, Simon, Portnow, Jana, Kim, Lyndon J., Loudon, William G., Thompson, Reid C., Avigan, David E., Fink, Karen L., Geoffroy, Francois J., Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E., Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P., Duma, Christopher, Etame, Arnold B., Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S., New, Pamela Z., Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J., Tse, Victor, Green, Richard M., Villano, John L., Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P., Maida, Anthony E., Prins, Robert M., Cloughesy, Timothy F., Mulholland, Paul, Bosch, Marnix L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975654/
https://www.ncbi.nlm.nih.gov/pubmed/29843811
http://dx.doi.org/10.1186/s12967-018-1507-6

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