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An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

Genome-wide methylation arrays are powerful tools for assessing cell composition of complex mixtures. We compare three approaches to select reference libraries for deconvoluting neutrophil, monocyte, B-lymphocyte, natural killer, and CD4+ and CD8+ T-cell fractions based on blood-derived DNA methylat...

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Detalles Bibliográficos
Autores principales:	Salas, Lucas A., Koestler, Devin C., Butler, Rondi A., Hansen, Helen M., Wiencke, John K., Kelsey, Karl T., Christensen, Brock C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975716/ https://www.ncbi.nlm.nih.gov/pubmed/29843789 http://dx.doi.org/10.1186/s13059-018-1448-7

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