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Roles of structural plasticity in chaperone HdeA activity are revealed by (19)F NMR

HdeA, a minimal ATP-independent acid chaperone, is crucial for the survival of enteric pathogens as they transit the acidic (pH 1–3) environment of the stomach. Although protein disorder (unfolding) and structural plasticity have been elegantly linked to HdeA function, the details of the linkage are...

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Detalles Bibliográficos
Autores principales: Zhai, Zining, Wu, Qiong, Zheng, Wenwen, Liu, Maili, Pielak, Gary J., Li, Conggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975942/
https://www.ncbi.nlm.nih.gov/pubmed/29910910
http://dx.doi.org/10.1039/c5sc04297f