Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines

Factor H binding protein (fHbp) is a major protective antigen in 4C-MenB (Bexsero(®)) and Trumenba(®), two serogroup B meningococcal vaccines, wherein expression level is a determinant of protection. Examination of promoter-containing intergenic region (IGR) sequences indicated that nine fHbp IGR al...

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Detalles Bibliográficos
Autores principales: Cayrou, Caroline, Akinduko, Ayodeji A., Mirkes, Evgeny M., Lucidarme, Jay, Clark, Stephen A., Green, Luke R., Cooper, Helen J., Morrissey, Julie, Borrow, Ray, Bayliss, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976157/
https://www.ncbi.nlm.nih.gov/pubmed/29847547
http://dx.doi.org/10.1371/journal.pone.0197186

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