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Epigenomes in Cardiovascular Disease

If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental di...

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Detalles Bibliográficos
Autores principales: Rosa-Garrido, Manuel, Chapski, Douglas J., Vondriska, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976233/
https://www.ncbi.nlm.nih.gov/pubmed/29798902
http://dx.doi.org/10.1161/CIRCRESAHA.118.311597
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author Rosa-Garrido, Manuel
Chapski, Douglas J.
Vondriska, Thomas M.
author_facet Rosa-Garrido, Manuel
Chapski, Douglas J.
Vondriska, Thomas M.
author_sort Rosa-Garrido, Manuel
collection PubMed
description If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies.
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spelling pubmed-59762332018-06-15 Epigenomes in Cardiovascular Disease Rosa-Garrido, Manuel Chapski, Douglas J. Vondriska, Thomas M. Circ Res Reviews If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies. Lippincott Williams & Wilkins 2018-05-25 2018-05-24 /pmc/articles/PMC5976233/ /pubmed/29798902 http://dx.doi.org/10.1161/CIRCRESAHA.118.311597 Text en © 2018 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
spellingShingle Reviews
Rosa-Garrido, Manuel
Chapski, Douglas J.
Vondriska, Thomas M.
Epigenomes in Cardiovascular Disease
title Epigenomes in Cardiovascular Disease
title_full Epigenomes in Cardiovascular Disease
title_fullStr Epigenomes in Cardiovascular Disease
title_full_unstemmed Epigenomes in Cardiovascular Disease
title_short Epigenomes in Cardiovascular Disease
title_sort epigenomes in cardiovascular disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976233/
https://www.ncbi.nlm.nih.gov/pubmed/29798902
http://dx.doi.org/10.1161/CIRCRESAHA.118.311597
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