Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (...

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Detalles Bibliográficos
Autores principales: Pearson, Craig S, Mencio, Caitlin P, Barber, Amanda C, Martin, Keith R, Geller, Herbert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976435/
https://www.ncbi.nlm.nih.gov/pubmed/29762123
http://dx.doi.org/10.7554/eLife.37139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976435/
https://www.ncbi.nlm.nih.gov/pubmed/29762123
http://dx.doi.org/10.7554/eLife.37139

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