Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation

Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel required for immune cell activation, insulin secretion, and body heat control. TRPM2 is activated by cytosolic Ca(2+), phosphatidyl-inositol-4,5-bisphosphate and ADP ribose. Here, we present the ~3 Å resolution el...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Tóth, Balázs, Szollosi, Andras, Chen, Jue, Csanády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976436/
https://www.ncbi.nlm.nih.gov/pubmed/29745897
http://dx.doi.org/10.7554/eLife.36409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976436/
https://www.ncbi.nlm.nih.gov/pubmed/29745897
http://dx.doi.org/10.7554/eLife.36409

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