Cargando…
Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel required for immune cell activation, insulin secretion, and body heat control. TRPM2 is activated by cytosolic Ca(2+), phosphatidyl-inositol-4,5-bisphosphate and ADP ribose. Here, we present the ~3 Å resolution el...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976436/ https://www.ncbi.nlm.nih.gov/pubmed/29745897 http://dx.doi.org/10.7554/eLife.36409 |