microRNAs in Neurodegeneration: Current Findings and Potential Impacts

Significant advancements have been made in unraveling and understanding the non-coding elements of the human genome. New insights into the structure and function of noncoding RNAs have emerged. Their relevance in the context of both physiological cellular homeostasis and human diseases is getting ap...

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Detalles Bibliográficos
Autores principales: Sharma, Salil, Lu, Hui-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976447/
https://www.ncbi.nlm.nih.gov/pubmed/29862137
http://dx.doi.org/10.4172/2161-0460.1000420
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author Sharma, Salil
Lu, Hui-Chen
author_facet Sharma, Salil
Lu, Hui-Chen
author_sort Sharma, Salil
collection PubMed
description Significant advancements have been made in unraveling and understanding the non-coding elements of the human genome. New insights into the structure and function of noncoding RNAs have emerged. Their relevance in the context of both physiological cellular homeostasis and human diseases is getting appreciated. As a result, exploration of noncoding RNAs, in particular microRNAs (miRs), as therapeutic agents or targets of therapeutic strategies is under way. This review summarizes and discusses in depth the current literature on the role of miRs in neurodegenerative diseases.
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spelling pubmed-59764472018-05-30 microRNAs in Neurodegeneration: Current Findings and Potential Impacts Sharma, Salil Lu, Hui-Chen J Alzheimers Dis Parkinsonism Article Significant advancements have been made in unraveling and understanding the non-coding elements of the human genome. New insights into the structure and function of noncoding RNAs have emerged. Their relevance in the context of both physiological cellular homeostasis and human diseases is getting appreciated. As a result, exploration of noncoding RNAs, in particular microRNAs (miRs), as therapeutic agents or targets of therapeutic strategies is under way. This review summarizes and discusses in depth the current literature on the role of miRs in neurodegenerative diseases. 2018-01-23 2018 /pmc/articles/PMC5976447/ /pubmed/29862137 http://dx.doi.org/10.4172/2161-0460.1000420 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Sharma, Salil
Lu, Hui-Chen
microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title_full microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title_fullStr microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title_full_unstemmed microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title_short microRNAs in Neurodegeneration: Current Findings and Potential Impacts
title_sort micrornas in neurodegeneration: current findings and potential impacts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976447/
https://www.ncbi.nlm.nih.gov/pubmed/29862137
http://dx.doi.org/10.4172/2161-0460.1000420
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